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Mitoxana

Mitoxana - General Information

Positional isomer of cyclophosphamide which is active as an alkylating agent and an immunosuppressive agent. [PubChem]

 

Pharmacology of Mitoxana

Mitoxana selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of ifosfamide-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.

 

Mitoxana for patients

 

Mitoxana Interactions

The physician should be alert for possible combined drug actions, desirable or undesirable, involving ifosfamide even though ifosfamide has been used successfully concurrently with other drugs, including other cytotoxic drugs.

 

Mitoxana Contraindications

Continued use of IFEX is contraindicated in patients with severely depressed bone marrow function. IFEX is also contraindicated in patients who have demonstrated a previous hypersensitivity to it.

 

Additional information about Mitoxana

Mitoxana Indication: For third line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna.
Mechanism Of Action: After metabolic activation, active metabolites of ifosfamide alkylate or bind with many intracellular molecular structures, including nucleic acids. The cytotoxic action is primarily due to cross-linking of strands of DNA and RNA, as well as inhibition of protein synthesis.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Ifosfamide
Synonyms: Asta Z 4942; Ifosfamid; Ifosfamide Sterile; Ifsofamide; Iphosphamid; Iphosphamide; Isophosphamide; Isofosfamide; I-Phosphamide
Drug Category: Antineoplastic Agents; Immunosuppressive Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Ifosfamide: Cyfos; Holoxan 1000; IFEX; Ifex/Mesnex Kit; Ifosfamide/Mesna Kit; Isoendoxan; Mitoxana; Naxamide;
Absorption: Not Available
Toxicity (Overdose): LD50 (mouse) = 390-1005 mg/kg, LD50 (rat) = 150-190 mg/kg. Side effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).
Protein Binding: Minimal
Biotransformation: Primarily hepatic
Half Life: 7-15 hours
Dosage Forms of Mitoxana: Powder, for solution Intravenous
Chemical IUPAC Name: N,3-bis(2-chloroethyl)-2-oxo-1-oxa-3-aza-2$l^{5}-phosphacyclohexan-2-amine
Chemical Formula: C7H15Cl2N2O2P
Ifosfamide on Wikipedia: http://en.wikipedia.org/wiki/Ifosfamide
Organisms Affected: Humans and other mammals